Sometimes end users experience slow network performance or request time outs as a result of an MTU value that is too high for the underlying network path.
The Maximum Transmission Unit (MTU) value set is too high for the network. This results in oversized packets getting fragmented or dropped, which causes latency or broken connections. Requests may only partly work or not work at all, depending on if the network can handle byte fragmentation.
Lowering the MTU Value will reduce throughput and can increase network latency.