A summary of the recommendations is to exclude these files and processes for all Citrix Apps:
For all Citrix components:
Set real-time scanning to scan local drives only and not network drives
Disable scan on boot
Remove unnecessary antivirus related entries from the Run key
Exclude the pagefiles from being scanned.
Note: When you make a path exclusion, we highly recommend that you add the exclusion to the smallest relevant scope of endpoints or - a specific group. For example, do not add exclusions to the default policy of the default group. Create a group of endpoints that use the application to exclude.