See the McAfee recommendations in this article: Endpoint Security and VirusScan Enterprise exclusions for Data Loss Prevention Endpoint to improve performance
A summary of the recommendations is to exclude these files:
C:\ProgramData\McAfee\
C:\Program File*\McAfee\
C:\Program File*\Common Files\McAfee\
C:\Windows\System32\mfevtps.exe
C:\ProgramData\McAfeeTmpInstall_Common\
C:\windows\TEMP\MfeEpAac.exe
C:\WINDOWS\TEMP\*\MfeEpAac.exe
C:\Users\*\AppData\Local\Temp\MfeEpAac_mfeprotect.exe
A more detailed and granular list that is less aggressive than the summary above is:
C:\Program Files\McAfee\Endpoint Security\Endpoint Security Platform\PwdUninstall.exe
C:\Program Files\McAfee\Endpoint Security\Threat Prevention\amcfg.exe
C:\Program Files\McAfee\Endpoint Security\Threat Prevention\AMcore\installer.exe
C:\Program Files\McAfee\Endpoint Security\Endpoint Security Platform\MfeVSCoreUninst.exe
C:\Program Files (x86)\McAfee\Endpoint Security\Endpoint Security Platform\VSCore_ENS_*\*\mfehidin.exe
C:\Program Files (x86)\McAfee\Endpoint Security\Threat Prevention\WscAVExe.exe
C:\Program Files (x86)\McAfee\Endpoint Security\Endpoint Security Platform\MaComServer.exe
C:\Program Files\Common Files\McAfee\SystemCore\mfemms.exe
C:\WINDOWS\system32\mfevtps.exe
C:\Program Files\McAfee\Endpoint Security\Endpoint Security Platform\mfeesp.exe
C:\Program Files\McAfee\Endpoint Security\Threat Prevention\mfetp.exe
C:\Program Files\Common Files\McAfee\SystemCore\mfecanary.exe
C:\WINDOWS\TEMP\*\MfeEpAac.exe
C:\Program Files\McAfee\Agent\x86\McScript_InUse.exe
C:\Program Files\Common Files\McAfee\SystemCore\EntVUtil.EXE
C:\Program Files (x86)\McAfee\VirusScan Enterprise\x64\scan64.exe
C:\Program Files (x86)\Common Files\McAfee\DATReputation\mcdatrep.exe
C:\Program Files\McAfee\Agent\x86\McScanCheck.exe
C:\Program Files (x86)\McAfee\VirusScan Enterprise\mfeann.exe
C:\Program Files\McAfee\Agent\macmnsvc.exe
C:\Program Files\McAfee\Agent\masvc.exe
C:\Program Files (x86)\McAfee\VirusScan Enterprise\VsTskMgr.exe
C:\Program Files\Common Files\McAfee\SystemCore\mfemms.exe
C:\Program Files\Common Files\McAfee\SystemCore\mcshield.exe
C:\Program Files\McAfee\Agent\x86\macompatsvc.exe
C:\Program Files\McAfee\Agent\x86\mfemactl.exe
C:\Program Files\McAfee\Agent\x86\UpdaterUI.exe
C:\Program Files (x86)\McAfee\VirusScan Enterprise\shstat.exe
C:\Program Files (x86)\McAfee\VirusScan Enterprise\mfeann.exe
C:\Program Files (x86)\McAfee\VirusScan Enterprise\VsTskMgr.exe
C:\Program Files\Common Files\McAfee\SystemCore\mfemms.exe
C:\Program Files\Common Files\McAfee\SystemCore\mcshield.exe
C:\Program Files (x86)\McAfee\VirusScan Enterprise\x64\scan64.exe
C:\Program Files (x86)\McAfee\VirusScan Enterprise\shstat.exe